The Effects of Psilocybin in Major Depressive Disorder (MDD).
1. Major depressive disorder (MDD).
Major depressive disorder (MDD) is one of the most common mental health conditions affecting millions of people worldwide. Despite the availability of several conventional treatments, many MDD patients do not respond adequately to these treatments and continue to struggle with symptoms such as persistent sadness, moodiness and loss of interest in daily activities. This has led researchers to look for alternative treatments that can effectively address MDD symptoms.
2. Psilocybin.
A promising alternative treatment is the use of psilocybin, a naturally occurring psychoactive substance found in certain fungal species. Psilocybin has been used for thousands of years in various cultural and spiritual contexts, and recent research has shown that it can have therapeutic benefits for people suffering from MDD.
Psilocybin is found in certain fungal species. The best known species of psilocybin-containing fungi are Psilocybe cubensis, Psilocybe semilanceata and Psilocybe azurescens. These species are commonly known as "magic mushrooms" due to their psychoactive effects. Other fungal species containing psilocybin include Psilocybe bohemica, Psilocybe cyanescens, and Psilocybe stuntzii.
3. The effects of psilocybin in major depressive disorder.
The phase 2 clinical trial, "The Effects of Psilocybin on Major Depressive Disorder" sponsored by Johns Hopkins University explored the use of psilocybin as a treatment for MDD. The objective was to determine the safety and efficacy of psilocybin in the treatment of depression, as well as the possible mechanisms of action underlying its therapeutic effects.
3.1 Patients.
Consequently, the study enrolled a large number of participants with a diagnosis of MDD. Participants received a single dose of psilocybin in a controlled and supportive environment and were followed for several weeks to assess their response to treatment. Primary study results included changes in depressive symptoms measured with the help of the Hamilton depression scale (GRID-HAMD), as well as any potential adverse effects.
The study involved 27 people in total, 16 women, 8 men and 3 people who withdrew from the clinical trial.
The trial is an important step in using psilocybin to treat MDD, and has the potential to offer new hope for those who have not responded to conventional treatments. If the results are positive, it could lead to the development of psilocybin as a safe and effective treatment for MDD, and could help improve the lives of millions of people worldwide.
3.2 Results.
Patients were divided into two groups, the first group received the dose of Psilocybin immediately and the second received the dose 8 weeks late.
Both groups of patients showed an improvement in their depression symptoms according to the GRID-HAMD scale, regardless of whether they received the dose of Psilocybin immediately or delayed.
It is important to note that psilocybin remains a Schedule I substance in the United States, meaning that it is considered to have a high potential for abuse and has no currently accepted medical use. However, with the growing body of evidence supporting its potential therapeutic benefits, there is hope that this classification may change in the future, allowing wider access to this promising treatment.
4. Conclusion of the study.
En conclusión, el ensayo clínico “Los efectos de la psilocibina en el trastorno depresivo mayor” es un desarrollo emocionante en la búsqueda de nuevos tratamientos para el MDD. Si bien se necesita mucha más investigación, los resultados de este estudio tienen el potencial de ser transformadores para las personas que luchan con la depresión y para traer nueva esperanza a aquellos que no han encontrado alivio a través de tratamientos convencionales.
Disclaimer.
The information provided on this platform is for educational purposes, under no circumstances are the results published here our property. The data were taken and plotted from the clinical trial with identification number NCT03181529 from the website ClinicalTrials.gov.
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